Best Enzyme Cleaners

3 Top Picks

Reviewers

10 Hours of Research

10 Considered Products

For most people, shopping for the best enzyme cleaner is about one thing and one thing alone. That being, to find an approved enzyme-based cleaner that’s designed to break down pet urine to permanently eliminate the smell.  

Sooner or later, even the best-trained pets in the world have the occasional accident. Though it’s usually during the potty-training process that pets are most likely to leave their mark all over the place at home. Pets bring incredible joy into our lives, but at the same time aren’t afraid to throw us the occasional curve ball. Precisely where reaching for the right cleaning product at the right time can make all the difference.

There’s a huge market for enzymatic carpet cleaners and enzyme odor removers, by which is the outright best enzyme cleaner when you’ve pets about the place?

In these independent rankings, we’ll be taking a look at some of the best enzyme cleaners for cat urine and arguably the best enzyme cleaners for dog urine you can buy online right now.

What Are Enzyme Cleaners?

Taking a quick look at the fundamentals first, an enzyme cleaner is a type of cleaning product that features enzymes in its composition. An enzyme is a macromolecular biological catalyst, which by accelerating chemical reactions help break down stains and odor-causing particles. Different types of enzymes are effective on different types of stains, though when incorporated in cleaning products can be particularly great at eliminating odors completely and permanently.

As touched upon above, there’s an extensive range of enzyme cleaning products available that are designed specifically for pet-friendly households. From puppies to kittens to rats to rabbits, a good enzyme cleaner can be just the thing for removing stains and restoring freshness to your home, if and when your pets leave you ‘gifts’ about the place.

Though primarily used to clean and refresh carpets and soft floor coverings, enzymatic cleaners can also be used on a wide variety of hard floors. Just as long as you check its compatibility with your floor covering, there’s a good chance it’ll do a fantastic job on just about any pet-related stain.

Top 3 Enzyme Cleaners

4.6/5

  • Certified by the Carpet and Rug Institute (CRI)
  • Suitable for a wide variety of surfaces
  • Exceptional overall value for money

4.4/5

  • A powerful commercial-strength formula
  • Permanently destroys stains and odors
  • Expert approved and recommended

4.7/5

  • Discourages pets from re-soiling the same spots
  • Compatible with a wide variety of materials
  • Great for more severe and extensive pet mess

Type of Enzymes

Getting to grips with the exact science of enzymes really isn’t necessary. The only thing you really need to know is that enzymatic cleaners use biological compounds to naturally break down stains and the particles that cause odors. The result of which being a clean, fresh and hygienic home – all unwanted ‘pet mess’ smells having been banished.

There are also enzyme-based products designed for cleaning drains, enzymatic laundry detergents and plenty more besides. Across the board, all enzyme cleaning products rely on four primary enzymes, briefly outlined below:

Proteases

This is an enzyme that effectively breaks down protein-based stains like blood, urine and wine. Or, described on a more scientific level on Wikipedia:

“A protease is a Trypsin that catalyzes proteolysis, the breakdown of proteins into smaller polypeptides or single amino acids. They do this by cleaving the peptide bonds within proteins by hydrolysis, a reaction where water breaks bonds.”

Lipases

This enzyme is extremely effective in breaking down fats, making it a great choice for grease and oil stains. Again, the more scientific description of lipases being:

“A lipase is any enzyme that catalyzes the hydrolysis of fats. Lipases are a subclass of the esterases. Lipases perform essential roles in digestion, transport and processing of dietary lipids in most, if not all, living organisms. Genes encoding lipases are even present in certain viruses.”

Amylases

Sugar, eggs and other starches are quickly and effectively broken down by this enzyme, which is described in detail as follows:

“An amylase is an enzyme that catalyses the hydrolysis of starch into sugars. Amylase is present in the saliva of humans and some other mammals, where it begins the chemical process of digestion.”

Cellulases

This is a naturally occurring enzyme which is the primary constituent of the vegetable fibers and plant cell walls. Cellulases are described on Wikipedia as:

“Cellulase is any of several enzymes produced chiefly by fungi, bacteria, and protozoans that catalyze cellulolysis, the decomposition of cellulose and of some related polysaccharides.”

How to choose an enzyme cleaner

Again, it’s worth pointing out that you don’t necessarily need to know the complex science behind enzyme cleaners to make them work for you. More than anything else, it’s simply a case of ensuring you pick up the right product for the right job.

Don’t make the mistake of assuming that any cleaning product that is enzyme-based will be suitable for every purpose around the home. If it’s an enzyme cleaner designed for unblocking drains or cleaning bathtubs, it’s probably not a good idea to use it on pet urine stains on the carpet.

Some enzyme cleaners claim to be ‘multipurpose’ to an extent, but there’s no such thing as a one-size-fits-all product for all purposes. Hence, you’ll want to keep a close eye on the following, when deciding which enzyme-based cleaner to go with.

Use Type

Checking where, when and with what kinds of stains the cleaner can be used is (of course) important. As is considering the method of application, given how spray bottles are much easier to control than huge jugs of solution. That said, larger pour bottles often represent better overall value for money.

Concentration

You’ll want to check the actual concentration of the formula on the label, rather than simply reading into its claims or slogans. There are plenty of formulas that are listed as ‘industrial strength’ or ‘commercial strength’, though aren’t always any more powerful or effective than a conventional household product.

Scent

If looking for a cleaner that’s going to bring a burst of freshness to your home, stick with those that are naturally fragranced where possible. Some of the artificial scents loaded into enzyme-based cleaners can be overpowering and borderline unpleasant. That said, it’s still better than the smell of pet pee in your carpets!

The Best Enzyme Cleaners

With the basics out of the way, we’ll now be taking a look at a selection of top-rated enzyme-based cleaners from a series of leading manufacturers. Each of the following having been tried, tested and approved by thousands of satisfied customers across the country:

Overview

First up, Rocco & Roxie Professional Strength Stain and Odor Eliminator is an exceptionally versatile and easy-to-use cleaner that’s also comprehensively safe.  Suitable for use on a wide variety of materials and floor coverings – everything from carpets and upholstery to hardwood and concrete - Rocco & Roxie Professional Strength Stain and Odor Eliminator provides a deep-down cleaning action and gets to work on stains and smells in no time.

As an added bonus, it’s also one of few cleaners in its category to be certified safe and effective by the Carpet and Rug Institute (CRI) for all colorfast carpets.  You can even toss a couple of cups in with a standard pre-wash laundry cycle, if looking to refresh and rejuvenate your clothes. Topped off with a 100% money-back guarantee if you’re not totally satisfied, this stuff is a top seller on Amazon for a good reason.

Features and Benefits

  • Easy-to use and comprehensively safe
  • Certified by the Carpet and Rug Institute (CRI)
  • Recommended by thousands of satisfied customers
  • Gets to work deep-down on stains and smells
  • Ships in complete with a 100% satisfaction guarantee
  • Suitable for a wide variety of surfaces
  • Exceptional overall value for money

Verdict

Again, there’s a reason why this is one of the top-selling products in its category on Amazon. Safe, effective, easy to use and affordable, it’s basically everything you’d expect from a market leading enzymatic. More importantly, it works…end of story!

4.6/5

Things We Liked

  • Certified by the Carpet and Rug Institute (CRI)
  • Suitable for a wide variety of surfaces
  • Exceptional overall value for money

Things We Didn't Like

  • Hard to eliminate strong urine

Overview

In contrast to my prior comments on the matter, Bubbas Super Strength Commercial Enzyme Cleaner is a high-performance enzymatic cleaner that really is commercial strength. Scientifically formulated to be significantly more potent and effective than most comparable home cleaning products, it’s just the thing for dealing with bigger and more challenging pet messes around the home.

That said, it’s also an exceptionally versatile enzyme-based stain remover for all areas of the home. From removing spot stains on furniture to cleaning kitty litter boxes to removing shoe odor, this stuff has a long list of useful applications. All from another safe and approved cleaning product that ships complete with a money back guarantee, so your cash is safe if you’re not completely happy.

Features and Benefits

  • A powerful commercial-strength formula
  • Versatile and easy to use
  • Expert approved and recommended
  • 100% money back guarantee
  • Permanently destroys stains and odors
  • Fantastic value for money


Verdict

Long story short – this is the kind of stuff you reach for when dealing with stains and stinks other products can’t touch. It’s also the kind of multipurpose cleaner you’ll always find a whole bunch of good uses for, both around the home and outdoors.

4.4/5

Things We Liked

  • A powerful commercial-strength formula
  • Permanently destroys stains and odors
  • Expert approved and recommended

Things We Didn't Like

  • Strong smell

Overview

Tried, tested and trusted for more than 35 years, Nature's Miracle Cat Advanced Stain and Odor Eliminator has been designed specifically with cat messes in mind. It uses a powerful bacteria-based formula to produce enzymes upon coming into contact with biological pet mess, wiping out stains and eliminating odors permanently.

Nature's Miracle Cat Advanced Stain and Odor Eliminator is particularly useful when dealing with severe and extensive cat mess – anything from pee to puke to diarrhea and so on. The powerful yet gentle formula can be used on a wide variety of surfaces and fabrics, with a one-gallon container option available for even better value for money. 

Features and Benefits

  • Gets to work on stains and odors in minutes
  • Backed by 35 years’ experience and expertise
  • Great for more severe and extensive pet mess
  • Discourages pets from re-soiling the same spots
  • 100% safe to use around the home
  • Compatible with a wide variety of materials
  • Excellent value for money


Verdict

Multipurpose enzymatic cleaning products have their points of appeal, but there’s really nothing better than this where cat-specific cleaning products are concerned. However severe or extensive the mess, Nature's Miracle Cat Advanced Stain and Odor Eliminator deals with it quickly, completely and in record time.

4.7/5

Things We Liked

  • Discourages pets from re-soiling the same spots
  • Compatible with a wide variety of materials
  • Great for more severe and extensive pet mess

Things We Didn't Like

  • Fragrance not good for asthma

Overview

On the lookout for a 100% natural cleaner that contains no chemicals or synthetic components whatsoever? Look no further than TriNova Natural Pet Stain and Odor Remover – an exceptionally capable enzyme-based cleaner that’s also completely natural. Safe to use on a wide variety of surfaces around the home, TriNova Natural Pet Stain and Odor Remover has been tried, tested and approved for the elimination of all different types of pet mess.

It’s also quick and easy to use – you simply spray it on the affected area, give it 5 minutes or so to do its thing and blot the solution away with a paper towel.  From carpets to hard floors to upholstery and so much more, TriNova Natural Pet Stain and Odor Remover is as versatile as it is safe to use around kids and pets. And if you’re not convinced, the 100% satisfaction guarantee has you covered.

Features and Benefits

  • A unique 100% natural formula
  • Professional quality cleaning action
  • Great for all types of pet mess
  • Suitable for iterative surfaces
  • Safe to use around kids and pets
  • Covered by a money-back guarantee
  • Very quick and easy to use

Verdict

TriNova Natural Pet Stain and Odor Remover demonstrates how you don’t always have to resort to harsh chemicals and synthetic compounds to get the job done. There’s nothing in this stuff that isn’t 100% natural, yet it performs just as well as (or even better than) most comparable chemical-based cleaners. All at a bargain price, as an added bonus.

4.4/5

Things We Liked

  • A unique 100% natural formula
  • Professional quality cleaning action
  • Safe to use around kids and pets

Things We Didn't Like

  • Strong fragrance

Overview

This is a brand that has been providing safe yet effective solutions for pet-friendly households for more than three decades. Designed to make light work of even the toughest and most unpleasant pet messes at home, TriNova Natural Pet Stain and Odor Remover uses an enzymatic action to destroy stains, neutralize odors and restore freshness.

TriNova Natural Pet Stain and Odor Remover also features a delicate floral scent, which is in no way unpleasant or overpowering. Made in the USA and approved for use on a wide variety of surfaces, TriNova Natural Pet Stain and Odor Remover is also designed to discourage pets from soiling the same spots repeatedly. It’s also 100% safe to use around kids and pets, bringing both peace of mind and a breath of fresh air to your interiors.

Features and Benefits

  • 30 years of pedigree and product knowledge
  • Removes all different kinds of pet stains
  • Features a unique pro-bacteria formula
  • Leaves behind a delicate floral fragrance
  • Safe to use around kids and pets
  • Suitable for use on most water-safe surfaces
  • Outstanding value for money

Verdict

The fact that TriNova Natural Pet Stain and Odor Remover has been a best-selling product in its bracket for such a long time says all that needs to be said about its quality and effectiveness. No gimmicks or false promises with this stuff – it performs every bit as well as the manufacturer promises. The floral scent is also a nice added touch, for a burst of freshness that’s far from overpowering.

4.5/5

Things We Liked

  • Removes all different kinds of pet stains
  • Features a unique pro-bacteria formula
  • Suitable for use on most water-safe surfaces

Things We Didn't Like

  • Doesn't work for strong stains

Overview

Created by pet lovers for pet lovers – the tagline this all-action enzyme cleaner goes by. Sunny & Honey Pet Stain & Odor Miracle Enzyme Cleaner is designed to work wonders with all different types of pet stains and odors, while at the same time being as safe and easy to use as it gets.

Backed by a full money-back guarantee, Sunny & Honey Pet Stain & Odor Miracle Enzyme Cleaner also brings the feel-good factor into the mix. 10% of all profits being donated by the company to animal shelters and animal rescues across the US, which is a pretty generous chunk of change. 

Features and Benefits

  • One of the highest rated enzyme cleaners available
  • Suitable for use on a wide variety of surfaces and materials
  • Safe to use around children and pets
  • Premium quality formula with a money back guarantee
  • 10% of all profits donated to animal charities
  • Superb overall value for money
  • Great for dealing with all different types of pet mess

Verdict

These guys have made it clear on countless occasions that they’re just as obsessed with animals as the rest of us. Which goes some way to explain why Sunny & Honey Pet Stain & Odor Miracle Enzyme Cleaner is such a fantastic product – safe, effective, easy to use, affordable and sold complete with a charitable donation with every purchase!

4.2/5

Things We Liked

  • Suitable for use on a wide variety of surfaces and materials
  • Great for dealing with all different types of pet mess
  • 10% of all profits donated to animal charities

Things We Didn't Like

  • Scent not a preference for some people

Overview

Let’s be honest – how could you not be sold on the spot by a cleaner with a name like this? MisterMax Anti-Icky-Poo has been designed to do it all and is described by the manufacturer as the ‘real deal’. Along with getting rid of all types of animal stinks from carpets and soft furnishings, MisterMax Anti-Icky-Poo is also non-toxic, 100% safe to use around kids and comprehensively environmentally friendly.

Easy to use and supplied in a large container for maximum value for money, MisterMax Anti-Icky-Poo also has a pretty darling picture on the label of two rather guilty looking pets. Not that this has any bearing on the quality of the product, but still – it’s the cherry on the cake for this outstanding all-round odor remover for pet friendly households.

Features and Benefits

  • Safe to use and environmentally friendly
  • Extremely effective and versatile
  • Ideal for all different types of pet mess
  • Quickly and completely eliminates problematic odors
  • Very impressive overall value for money
  • Backed by thousands of satisfied customers
  • Satisfaction guaranteed by the manufacturer

Verdict

The packaging may give the impression of a cute and cuddly product, but this stuff means business – big time. However extensive or problematic the stain or stink you’re dealing with, its powerful enzyme-based formula is (literally) guaranteed to get the job done in no time. An affordable cleaning product that’s well and truly worth its weight in gold.

4.4/5

Things We Liked

  • Safe to use and environmentally friendly
  • Extremely effective and versatile
  • Very impressive overall value for money

Things We Didn't Like

  • May leave occasional residue

Overview

Boasting a unique formula that contains plant-based surfactants, citrus extract and enzyme-producing cultures, Biokleen Bac-Out Natural Enzyme Stain and Odor Remover take all-round freshness to an entirely new level. Its all-natural scent brings the most beautiful breath of fresh air to your interior spaces, making it just the thing for dealing with irritating odors.

Biokleen Bac-Out Natural Enzyme Stain and Odor Remover is ready to use right out of the container and is approved as safe for use around children and pets – even birds. It’s also highly-recommended for those with allergies and chemical sensitivities, due to the complete exclusion of artificial colors and fragrances.

Features and Benefits

  • Features a 100% unique formula
  • Quality ingredients with no artificial fragrance
  • Ideal for those with allergies and chemical sensitivities
  • Safe to use around pets and children
  • Very easy to use and exceptionally effective
  • Outstanding overall value for money
  • Leaves behind a beautiful citrus fragrance

Verdict

Biokleen Bac-Out Natural Enzyme Stain and Odor Remover demonstrates why it really isn’t necessary to pollute quality enzyme cleaning products with overpowering artificial fragrances. With its beautiful all-natural lemon scent, problematic pet pongs are replaced with the most wonderful lingering freshness around the entire home.

4.1/5

Things We Liked

  • Quality ingredients with no artificial fragrance
  • Safe to use around pets and children
  • Ideal for those with allergies and chemical sensitivities

Things We Didn't Like

  • poor packaging

Overview

Bearing the brand of the retail giant itself, AmazonCommercial enzyme cleaner is a no-nonsense enzymatic cleaner up for grabs at a bargain price.  A true multi-purpose cleaner that’s suitable for use in all areas of the home, AmazonCommercial enzyme cleaner is just as good at dealing with floors, drains and septic tanks as it is everyday pet mess.

Despite being up for grabs at a rock bottom price, AmazonCommercial enzyme cleaner has more than enough power and potency to be suitable for commercial and industrial spaces. The formula features a pleasant minty scent for an added burst of freshness, as part of a non-caustic, non-acidic, nonflammable and non-corrosive cleaning product that’s an absolute breeze to use.

Features and Benefits

  • Supplied in a large container for maximum value for money
  • Ideal for use in homes, commercial premises and hospitality settings
  • An extremely versatile multi-purpose cleaner
  • Great for getting rid of problematic pet stains and odors
  • Refreshing minty fragrance 
  • Great overall value for money

Verdict

This could well be as close as you’re ever likely to get to a genuine all-purpose enzyme-based cleaning product. Some pet-friendly households naturally gravitate towards enzymatic cleaners designed specifically for pet mess. But if you’re looking for something you can use all over the place on an everyday basis, AmazonCommercial enzyme cleaner takes some beating – especially at this kind of price.

4.5/5

Things We Liked

  • Great overall value for money
  • Refreshing minty fragrance 
  • Ideal for use in homes, commercial premises and hospitality settings

Things We Didn't Like

  • Doesn't work on all materials

Overview

Last but not least comes ANGRY ORANGE Ready-to-Use Citrus Enzymatic Cleaner, which for its fragrance alone is absolutely worth checking out.  Bursting with beautiful citrus freshness, this unique formula smells just like fresh-squeezed oranges because it is made from oranges. Boasting twice the odor-fighting power of many comparable cleaners, ANGRY ORANGE Ready-to-Use Citrus Enzymatic Cleaner gets to work on even the toughest pet mess in a matter of minutes.

Along with being suitable for use on a wide variety of surfaces, ANGRY ORANGE Ready-to-Use Citrus Enzymatic Cleaner is also approved as safe for use around pets and kids. Ready to use right out of the container and with no mixing required, ANGRY ORANGE Ready-to-Use Citrus Enzymatic Cleaner is perhaps the ultimate dog and cat stain deodorizer you’ll wonder how you ever got by without.

Features and Benefits

  • A simply stunning citrus-fresh fragrance
  • Made with high quality natural ingredients
  • Ready to use straight out of the container
  • Safe to use around kids and pets
  • Up to twice the odor-fighting power
  • Long lasting for great value for money

Verdict

The cleaning power of this stuff is great, but it really stands out for its natural orange fragrance. Assuming you like citrus, you’re unlikely to find a more refreshing or revitalizing enzymatic cleaner for dealing with pet mess in all areas of the home.

4.5/5

Things We Liked

  • Made with high quality natural ingredients
  • Ready to use straight out of the container
  • Long lasting for great value for money

Things We Didn't Like

  • Weaker on cat urine
Tiffany Wong
 

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